Zic3 Background Information Zic3 (zinc finger protein of the cerebellum 3) is a C2H2 zinc finger transcription factor that establishes a proper left-right axis and midline neural patterning during early development of the vertebrate embryo. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. Zic3 mutations in the zinc finger DNA binding domain and in the N-terminal domain result in loss of reporter gene transactivation, and mutations between amino acids 253-323 of the Zic3 protein causes aberrant cytoplasmic localization rather than the wild type nuclear localization.
Zic3 (N-19)
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Zic3 (N-19): sc-28154. Western blot analysis of Zic3 expression in NIH/3T3 (A) and Rat2 (B) whole cell lysates.
Zic3 (N-19): sc-28154. Western blot analysis of Zic3 expression in Y79 whole cell lysate.
