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Sodium taurocholate (CAS 145-42-6) - chemical structure image
Molecular structure of Sodium taurocholate, CAS Number: 145-42-6
Sodium taurocholate (CAS 145-42-6) - chemical structure image
Molecular structure of Sodium taurocholate, CAS Number: 145-42-6
Molecular structure of Sodium taurocholate, CAS Number: 145-42-6

Sodium taurocholate (CAS 145-42-6)

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Alternate Names:
Taurocholic Acid, Sodium Salt
Application:
Sodium taurocholate is a detergent useful for the solubilization of lipids and membrane-bound proteins
CAS Number:
145-42-6
Purity:
≥97%
Molecular Weight:
537.69
Molecular Formula:
C26H44NO7S•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

Sodium taurocholate (NaT) is a detergent useful for the solubilization of lipids and membrane-bound proteins. It is a natural surfactant that is found in bile, and is used in laboratory experiments to study the effects of bile acids on cells, tissues, and gene and protein expression. It has been used in a variety of research applications, including drug delivery, cell culture, and biochemistry. Sodium taurocholate has been found to have several beneficial effects, including increased cell viability and increased membrane permeability. In addition, it has anti-inflammatory, anti-tumor, and anti-cancer properties. Aggregation number 4. CMC 3–11 mM. Micellar weight 2100. pKa 1.9.


Sodium taurocholate (CAS 145-42-6) References

  1. Retraction note on: The influence of sodium hyaluronate, l-leucine and sodium taurocholate on the nebulization of aqueous betamethasone-17-valerate suspensions.  |  Tadros, MI. 2009. AAPS PharmSciTech. 10: 807. PMID: 19533370
  2. Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes.  |  Zhong, G., et al. 2013. J Virol. 87: 7176-84. PMID: 23596296
  3. Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes.  |  Lempp, FA., et al. 2017. Hepatology. 66: 703-716. PMID: 28195359
  4. SRT1720 ameliorates sodium taurocholate-induced severe acute pancreatitis in rats by suppressing NF-κB signalling.  |  Shi, C., et al. 2018. Biomed Pharmacother. 108: 50-57. PMID: 30216799
  5. Role of Sodium Taurocholate Cotransporting Polypeptide as a New Reporter and Drug-Screening Platform: Implications for Preventing Hepatitis B Virus Infections.  |  Wu, MR., et al. 2020. Mol Imaging Biol. 22: 313-323. PMID: 31140111
  6. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice.  |  Zhang, X., et al. 2020. Biol Pharm Bull. 43: 985-993. PMID: 32475920
  7. Sodium taurocholate increases hydraulic conductivity in rabbit collecting tubule.  |  Dillingham, MA., et al. 1988. Kidney Int. 33: 782-6. PMID: 3386133
  8. Clinical features of sodium-taurocholate cotransporting polypeptide deficiency in pediatric patients: case series and literature review.  |  Zou, TT., et al. 2021. Transl Pediatr. 10: 1045-1054. PMID: 34012853
  9. Spermine with Sodium Taurocholate Enhances Pulmonary Absorption of Macromolecules in Rats.  |  Miyake, M., et al. 2021. J Pharm Sci. 110: 3464-3470. PMID: 34118254
  10. Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice.  |  Serra, MB., et al. 2021. J Vis Exp.. PMID: 34251363
  11. Binding of Hepatitis B Virus Pre-S1 Domain-Derived Synthetic Myristoylated Peptide to Scavenger Receptor Class B Type 1 with Differential Properties from Sodium Taurocholate Cotransporting Polypeptide.  |  Hinuma, S. and Kuroda, S. 2022. Viruses. 14: PMID: 35062309
  12. Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct.  |  Zhou, X., et al. 2022. J Vis Exp.. PMID: 35435891
  13. Influence of dietary sodium taurocholate on the growth performance and liver health of Nile tilapia (Oreochromis niloticus).  |  Ding, FF., et al. 2022. Fish Physiol Biochem.. PMID: 36044098
  14. Analysis of absorption-enhancing mechanisms for combinatorial use of spermine with sodium taurocholate in Caco-2 cells.  |  Maruyama, M., et al. 2022. Eur J Pharm Biopharm. 180: 332-343. PMID: 36307000
  15. Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.  |  Guo, F., et al. 2022. Pancreas. 51: 739-746. PMID: 36395397

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Product NameCatalog #UNITPriceQtyFAVORITES

Sodium taurocholate, 5 g

sc-281163
5 g
$118.00

Is this product synthetic?

Asked by: hawkeye11
This chemical, Sodium taurocholate (CAS 145-42-6), is considered synthetic.
Answered by: Chemical Support 1
Date published: 2019-09-10

i wanna use it in beta glucoside enzyme assay for the diagnosis of gaucher's disease. would it work for these specifications?

Asked by: kkkkkkkk
Thank you for your question. We do not have any information about whether or not this chemical, Sodium taurocholate (CAS 145-42-6), can be used in that application. However, please be advised that all chemicals provided by Santa Cruz Biotechnology are intended for research use only. They are not suitable for diagnostic or therapeutic use.
Answered by: Technical Support
Date published: 2016-12-28
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Rated 3 out of 5 by from Took 3 monthsIt took about 3 months until I received it. However, its quality was as expected.
Date published: 2016-12-05
Rated 5 out of 5 by from FanFan, et al. (PubMed ID 26364660) used sodium taurocholate to induce acute pacreatitis in rats. -SCBT Publication Review
Date published: 2015-05-25
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Sodium taurocholate is rated 4.0 out of 5 by 2.
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