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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of YY1 of human origin
- recommended for detection of YY1 and, to a lesser extent, YY2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-281 P
- agarose conjugate for IP studies, sc-281 AC, 500 µg/0.25 ml agarose
- TransCruz reagent for Gel Supershift and ChIP applications, sc-281 X, 200 µg/0.1 ml
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YY1 Background Information
The YY1 transcription factor, also known as NF-E1 (human) and Delta or UCRBP (mouse) is of interest due to its diverse effects on a wide variety of target genes. YY1 is broadly expressed in a wide range of cell types and contains four C-terminal zinc finger motifs of the Cys-Cys-His-His type and an unusual set of structural motifs at its N-terminal. It binds to downstream elements in several vertebrate ribosomal protein genes, where it apparently acts positively to stimulate transcription and can act either negatively or positively in the context of the immunoglobulin k 3’ enhancer and immunoglobulin heavy-chain µE1 site as well as the P5 promoter of the adeno-associated virus. It thus appears that YY1 is a bifunctional protein, capable of functioning as an activator in some transcriptional control elements and a repressor in others.
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See how others have used YY1 (C-20): sc-281 antibody and or YY1 (C-20) antibody conjugates.
48 total citations Loading citations.
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YY1 (C-20)
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YY1 (C-20): sc-281. Western blot analysis of YY1 expression in HeLa (A), A-431 (B), Y79 (C) and NIH/3T3 (D) whole cell lysates.
YY1 (C-20): sc-281. Western blot analysis of YY1 expression in non-transfected: sc-117752 (A) and mouse YY1 transfected: sc-124689 (B) 293T whole cell lysates. YY1 (C-20): sc-281. Western blot analysis of YY1 expression in non-transfected: sc-117752 (A) and human YY1 transfected: sc-172170 (B) 293T whole cell lysates. YY1 (C-20): sc-281. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing nuclear and cytoplasmic staining of glandular cells.
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