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Malformin C (CAS 59926-78-2)

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Application:An inhibitor of bleomycin-induced G2 arrest
CAS Number:59926-78-2
Molecular Weight:529.72
Molecular Formula:C23H39N5O5S2
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Malformin C sc-280953 250 µg $103
Malformin C sc-280953A 1 mg $320
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
Inhibitor of bleomycin-induced G2 arrest. Has antibacterial, antimalarial and antitrypanosomal activity. Induces root curvature and malformation in plants and enhances fibrinolytic activity in plants.
Technical Information
Appearance:White
Solubility:Soluble in 100% ethanol, chloroform, DMSO, and methanol. Insoluble in water.
Storage:Store at -20° C
Boiling Point:921.28 °C at 760 mmHg (Predicted)
Refractive Index:n20D 1.50 (Predicted)
IC50:Abrogate the bleomycin (Prod. No. BML-AP302)-induced G2 arrest: IC50 = 0.9 nM (Jurkat cells); Plasmodium falciparum: EC5050 = 163.6 nM
Safety and Reference Information
Transport:UN 2811, Class 6.1, Packing group III
PubChem CID:23983656
SMILES:CCC(C)[C@H]1C(=O)N[C@@H]2CSSC[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)C(C)CC)C (C)C)NC2=O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
Curvatures and Malformations in Bean Plants Caused by Culture Filtrate of Aspergillus niger.: R.W. Curtis ; Plant Physiol. 33, 17 (1958) Abstract; Full Text Root curvatures induced by culture filtrates of Aspergillus niger.: R.W. Curtis ; Science 128, 661 (1958) Abstract Antibiotic properties of malformin.: S. Suda & R.W. Curtis ; Appl. Microbiol. 14, 475 (1966) Abstract; Full Text Enhancement of fibrinolytic activity of U937 cells by malformin A1.: Y. Koizumi & K. Hasumi; J. Antibiot. 55, 78 (2002) Abstract Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells.: K. Hagimori, et al. ; Biol. Pharm. Bull. 30, 1379 (2007) Abstract Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest.: Y. Kojima, et al. ; J. Antibiot. 61, 297 (2008) Abstract Solid-phase synthesis and biological activity of malformin C and its derivatives.: Y. Kojima, et al.; J. Antibiot. Epub ahead of print , (2009)
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