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home » Kinases and Phosphatases » MEK kinase Antibody / MEK kinase Antibodies » p-MEK kinase-3 (Ser 337): sc-28044

p-MEK kinase-3 (Ser 337) Antibody: sc-28044

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-28044-R
  • epitope corresponding to phosphorylated Ser 337 of MEK kinase-3 of human origin
  • recommended for detection of Ser 337 phosphorylated MEK kinase-3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine
  • blocking peptide, sc-28044 P
 
Additional MEK kinase Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MAP3K3 4215 17q23.3 NM_002401, NM_203351 Q99759
 602539
Mouse Map3k3 26406 11 E1 Q61084
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-MEK kinase-3 (Ser 337) sc-28044 200 µg/ml $279
p-MEK kinase-3 (Ser 337) P sc-28044 P
(peptide)
 100 µg/0.5 ml $61
p-MEK kinase-3 (Ser 337)-R sc-28044-R 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 siRNA (h) sc-39108 10 µM $258
MEK kinase-3 (h)-PR sc-39108-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 shRNA Plasmid (h) sc-39108-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 shRNA (h) Lentiviral Particles sc-39108-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 (m): 293T Lysate sc-125599 100µg/200µl $205

MEK kinase-3 Background Information
Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also called MAP kinase kinase kinases) phosphorylate and activate the MAP kinases, including ERK, JNK and p38. The MEK kinases characterized to date include Raf-1, Raf-B, MOS, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (also designated MEK kinase-5). MEK kinase-1 has been shown to phosphorylate MEK-1 via a Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK pathway. ASK1 activates both MEK-4 and MEK-3/MEK-6 pathways. SGK1 inhibits MEK-3-MKK3/6 signal transduction by phosphorylation of MEK-3 on Ser166 and Ser337.
p-MEK kinase-3 (Ser 337)
Click on image to enlarge
sc-28044
p-MEK kinase-3 (Ser 337)-R: sc-28044-R. Western blot analysis of MEK kinase-3 phosphorylation in non-transfected: sc-117752 (A) and mouse MEK kinase-3 transfected: sc-125599 (B) 293T whole cell lysates.
sc-28044
Western blot analysis of MEK kinase-3 phosphorylation in non-transfected: sc-117752 (A,D), untreated mouse MEK kinase-3 transfected: sc-125599 (B,E) and lambda protein phosphatase (sc-200312A) treated mouse MEK kinase-3 transfected: sc-125599 (C,F) 293T whole cell lysates. Antibodies tested include p-MEK kinase-3 (Ser 337)-R: sc-28044-R (A,B,C) and MEK kinase-3 (40): sc-136260 (D,E,F).
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