Date published: 2025-9-13

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Saponin (CAS 8047-15-2)

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Application:
Saponin is an amphipathic glycoside and surfactant
CAS Number:
8047-15-2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Saponin is a secondary metabolite that facilitates the penetration of proteins through the cell membrane. Studies indicate that saponins are amphipathic glycosides, which can act as hemolytic agents. Research indicates that Saponin displays antinociceptive, anti-inflammatory and antipyretic activities, which may be due to its nonglycosidic moiety, sapogenin. Saponin can also be used in environmental research to recover chromium and other metals from sludge samples. Additional studies indicate that Saponin is useful in immunoassays since it can stimulate the Th1 immune response and the production of cytotoxic T-lymphocytes in response to exogenous antigens.


Saponin (CAS 8047-15-2) References

  1. Advances in saponin-based adjuvants.  |  Sun, HX., et al. 2009. Vaccine. 27: 1787-96. PMID: 19208455
  2. Chromium recovery from tannery sludge with saponin and oxidative remediation.  |  Kiliç, E., et al. 2011. J Hazard Mater. 185: 456-62. PMID: 20940084
  3. Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice.  |  Arrau, S., et al. 2011. J Ethnopharmacol. 133: 164-7. PMID: 20951193
  4. Surface properties and foamability of saponin and saponin-chitosan systems.  |  Santini, E., et al. 2019. Colloids Surf B Biointerfaces. 181: 198-206. PMID: 31136951
  5. Saponin Facilitates Anti-Robo1 Immunotoxin Cytotoxic Effects on Maxillary Sinus Squamous Cell Carcinoma.  |  Komatsu, N., et al. 2020. J Oncol. 2020: 9593516. PMID: 32256588
  6. Adjuvant effect of saponin in an oil-based monovalent (serotype O) foot-and-mouth disease virus vaccine on the antibody response in guinea pigs and cattle.  |  Bazid, AI., et al. 2021. Arch Virol. 166: 1977-1984. PMID: 33871696
  7. Saponin Stabilization via Progressive Freeze Concentration and Sterilization Treatment.  |  Osman, WNAW., et al. 2021. Molecules. 26: PMID: 34443445
  8. Evaluation of the Saponin Content in Panax vietnamensis Acclimatized to Lam Dong Province by HPLC-UV/CAD.  |  Nguyen, HT., et al. 2021. Molecules. 26: PMID: 34500805
  9. Analysis of the mechanism of saponin biotransformation in Dioscoreae nipponicae rhizoma by the endophytic fungus Fusarium sp. C39 using whole-genome sequencing.  |  Ding, C., et al. 2022. J Basic Microbiol. 62: 623-633. PMID: 35411947
  10. Association of saponin concentration, molecular markers, and biochemical factors with enhancing resistance to alfalfa seedling damping-off.  |  Azzam, CR., et al. 2022. Saudi J Biol Sci. 29: 2148-2162. PMID: 35531163
  11. Saponin and chitosan-based oral vaccine against viral haemorrhagic septicaemia virus (VHSV) provides protective immunity in olive flounder (Paralichthys olivaceus).  |  Jung, MH., et al. 2022. Fish Shellfish Immunol. 126: 336-346. PMID: 35643353
  12. Encapsulated saponin by ferritin nanoparticles attenuates the murine pneumococcal pneumonia.  |  Safdarpour, S., et al. 2022. Microb Pathog. 172: 105731. PMID: 36041710
  13. Saponin attenuates diesel exhaust particle (DEP)-induced MUC5AC expression and pro-inflammatory cytokine upregulation via TLR4/TRIF/NF-κB signaling pathway in airway epithelium and ovalbumin (OVA)-sensitized mice.  |  Jo, S., et al. 2022. J Ginseng Res. 46: 801-808. PMID: 36312733
  14. Surface Properties of Saponin-Chitosan Mixtures.  |  Krzan, M., et al. 2022. Molecules. 27: PMID: 36364333
  15. Preparation of β-cyclodextrin/polysaccharide foams using saponin.  |  Petitjean, M. and Isasi, JR. 2023. Beilstein J Org Chem. 19: 78-88. PMID: 36761472

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Saponin, 25 g

sc-280079
25 g
$43.00

Saponin, 100 g

sc-280079A
100 g
$108.00

Saponin, 1 kg

sc-280079B
1 kg
$989.00

Hello what is the purity of this product meaning? I want to use for analysis of yield of saponin content in plants. Is that okay?

Asked by: Cara
Thank you for your question. The purity of Saponin (CAS 8047-15-2) is based on saponin content on a dry basis. The native source is Quillaja bark. Each lot of this chemical comes with a lot-specific Certificate Of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate Of Analysis on our website. Alternatively, please contact our Technical Service Department to inquire about the purity of our most recent lot. We do not have any references regarding the use of saponin for analysis of yield in plants. We would recommend you consult the primary literature.
Answered by: Technical Support
Date published: 2024-03-18

What is the molecular weight?

Asked by: Io5ay
Thank you for your question. This has no specified molecular weight for this compound because the number of saccharide chains attached to the sapogenin/aglycone core can vary as can the length of each chain. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-22
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Rated 4 out of 5 by from Works well in our plant cellsWorks well in our plant cells.
Date published: 2015-09-30
Rated 5 out of 5 by from Kili et alKili et al. (PubMed ID 20940084) used saponin, a biosurfactant, to extract Chromium from tannery sludge at a low pH. -SCBT Publication Review
Date published: 2015-03-28
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Saponin is rated 4.5 out of 5 by 2.
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