goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-28006-R
epitope corresponding to dually phosphorylated Thr 598 and Ser 601 of Raf-B of human origin
recommended for detection of Thr 598 and Ser 601 dually phosphorylated Raf-B of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Raf-B Background Information Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-terminal domain. Raf-A, a second member of the Raf gene family of serine/threonine protein kinases, exhibits substantial homology to Raf-1 within the kinase domain of the two molecules, but less homology elsewhere. Expression of Raf-B is highly restricted with highest levels in the cerebrum and testis.
p-Raf-B (Thr 598/Ser 601) Product Citations
See how others have used p-Raf-B (Thr 598/Ser 601): sc-28006 antibody and or p-Raf-B (Thr 598/Ser 601) antibody conjugates.
