epitope mapping near the C-terminus of protection of telomeres 1 of human origin
recommended for detection of POT1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and porcine
POT1 Background Information POT1 (protection of telomeres 1 homolog (S. pombe)) human protein mediates chromosome end-protection and telomere-length regulation and has a strong sequence preference for binding telomeric repeat tracts. POT1 can disrupt telomeric repeat tracts that form intramolecular G-quadruplexes through Hoogsteen base-pairing. POT1 belongs to a family of oligonucleotide-binding (OB)-fold-containing proteins that include Oxytricha nova TEBP, Cdc13 and spPot1, which specifically recognize telomeric single-stranded DNA (ssDNA). Telomere maintenance involves the cooperation of several telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1. Alterations in POT1 expression levels may be associated with stomach carcinogenesis and GC progression.
