Aurora A Background Information Activation of the oncogenic protein kinase Aurora A regulates meiotic and mitotic cell cycles in eukaryotic cells. Specifically, Aurora A plays a key role in G2/M progression. Activation occurs via autophosphorylation, and while 14 sites are subject to this, only the threonine residue at position 295 is required for activity. Though autophosphorylation mediates activation, a number of other proteins influence activation, including the spindle assembly factor TPX2 and p53.
Aurora A (xG-14)
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Aurora A (xG-14): sc-27884. Western blot analysis of Aurora A expression in A6 (A) and XLK-WG (B) whole cell lysates.
