santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Transcription Regulators » TSC-22 Antibody / TSC-22 Antibodies » TSC-22 (N-16): sc-27842

TSC-22 (N-16) Antibody: sc-27842

  |  Datasheet
  • goat polyclonal IgG, 200µg/ml
  • epitope mapping at the N-terminus of TSC-22 of human origin
  • recommended for detection of TSC-22 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including bovine, porcine and avian
  • blocking peptide, sc-27842 P
 
Additional TSC-22 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TSC22D1 8848 13q14.11 Q15714
 607715
Mouse Tsc22d1 21807 14 D3 P62500
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 (N-16) sc-27842 200 µg/ml $279
TSC-22 (N-16) P sc-27842 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 siRNA (h) sc-44174 10 µM $258
TSC-22 siRNA (m) sc-154710 10 µM $258
TSC-22 (h)-PR sc-44174-PR 10 µM $23
TSC-22 (m)-PR sc-154710-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 shRNA Plasmid (h) sc-44174-SH 20 µg $520
TSC-22 shRNA Plasmid (m) sc-154710-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 shRNA (h) Lentiviral Particles sc-44174-V 200 µl $625
TSC-22 shRNA (m) Lentiviral Particles sc-154710-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104

TSC-22 Background Information
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptional regulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPAR© signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.