RhAG Antibody (Y-20): sc-27810

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The Rh proteins in the red blood cell form a complex made up of one D-subunit, one CE-subunit, and two Rh-associated glycoprotein (RHAg) subunits. Along with its antigenic properties, this complex functions as a major interaction site between the membrane lipid bilayer and the cytoskeleton of the red cell, via ankyrin-R interaction with the C-terminal cytoplasmic domain of the Rh and RHAg proteins. Furthermore, studies comparing ammonium concentration in normal and Rh(null) red cells show that the complex also contributes to ammonium export from the cells. Rh(null) is a rare autosomal recessive disorder characterized by an absence of Rh antigens and a varying degree of hemolytic anemia and spherostomatocytosis. The associated genetic mutations effect the transmembrane domain of the protein, correlating the structural defect with the loss of transport function characteristic in these cells.