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CD77 synthase (W-18) Antibody: sc-27697 |
| Datasheet |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within a lumenal domain of CD77 synthase of human origin
- recommended for detection of CD77 synthase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- blocking peptide, sc-27697 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
A4GALT |
53947 |
22q13.2 |
NM_017436 |
Q9NPC4
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607922 |
| Mouse |
A4galt |
239559 |
15 E1 |
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Q67BJ4
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N/A |
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CD77 synthase Background Information
Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The highest tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very high levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, leading to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions. |
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CD77 synthase (W-18)
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CD77 synthase (W-18): sc-27697. Western blot analysis of CD77 synthase expression in Daudi whole cell lysate.
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