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home » Synthesis and Degradation » HMGCR Antibody / HMGCR Antibodies » HMGCR (K-15): sc-27580

HMGCR (K-15) Antibody: sc-27580

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping near the C-terminus of HMGCR of human origin
  • recommended for detection of HMGCR of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-27580 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-27580 X, 200 µg/0.1 ml
 
Additional HMGCR Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IF   Gel Shift   ChIP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human HMGCR 3156 5q13.3 NM_000859 P04035
 142910
Mouse Hmgcr 15357 13 D1 Q01237
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
HMGCR (K-15) sc-27580 200 µg/ml $279
HMGCR (K-15) P sc-27580 P
(peptide)
 100 µg/0.5 ml $61
HMGCR (K-15) X sc-27580 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HMGCR siRNA (h) sc-43838 10 µM $258
HMGCR siRNA (m) sc-44851 10 µM $258
HMGCR siRNA (h)-PR sc-43838-PR 10 µM $23
HMGCR siRNA (m)-PR sc-44851-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HMGCR shRNA Plasmid (h) sc-43838-SH 20 µg $520
HMGCR shRNA Plasmid (m) sc-44851-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HMGCR shRNA (h) Lentiviral Particles sc-43838-V 200 µl $625
HMGCR siRNA shRNA (m) Lentiviral Particles sc-44851-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104

HMGCR Background Information
The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.

HMGCR (K-15) Product Citations
See how others have used HMGCR (K-15): sc-27580 antibody and or HMGCR (K-15) antibody conjugates.


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