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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of HMGCR of human origin
- recommended for detection of HMGCR of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine, porcine and avian
- blocking peptide, sc-27578 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-27578 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HMGCR |
3156 |
5q13.3 |
NM_000859 |
P04035
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142910 |
| Mouse |
Hmgcr |
15357 |
13 D1 |
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Q01237
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N/A |
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HMGCR Background Information
The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert anti-inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.
| HMGCR (C-18) Product Citations |
See how others have used HMGCR (C-18): sc-27578 antibody and or HMGCR (C-18) antibody conjugates.
4 total citations Loading citations.
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HMGCR (C-18)
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HMGCR (C-18): sc-27578. Western blot analysis of HMGCR membrane-bound glycoprotein expression and HMGCR C-terminal cleavage product expression in Hep G2 (A) and TT (B) whole cell lysates.
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