epitope mapping near the C-terminus of BMP-6 of human origin
recommended for detection of precursor and mature BMP-6 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
BMP-6 Background Information Bone morphogenic proteins (BMPs) are members of the TGF∫ superfamily (1,2). BMPs are involved in the induction of cartilage and bone formation (3). In vivo studies have shown that BMP-2 (also designated BMP-2A) and BMP-3 can independently induce cartilage formation (3). Smad3 association with the TGF∫ receptor complex and Smad1 translocation to the nucleus are observed after the addition of BMP-4 (also designated BMP-2B), suggesting that BMP-4 may play a role in activation of the Smad pathway (4,5). BMP-5, BMP-6 and BMP-7 all share high sequence homology with BMP-2, indicating that they each may be able to induce cartilage formation (6,7). BMP-8 (also designated OP-2) is thought to be involved in early development, as detectable expression has not been found in adult organs (8).
BMP-6 (D-19) Product Citations
See how others have used BMP-6 (D-19): sc-27409 antibody and or BMP-6 (D-19) antibody conjugates.
