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PDZK1 Antibody (L-12): sc-27279

 |  Datasheet

(Based on data analysis)

  • PDZK1 Antibody (L-12) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of PDZK1 of human origin
  • recommended for detection of PDZK1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including porcine
  • blocking peptide, sc-27279 P
 

See additional PDZK Antipdzkbodies including PDZK Antipdzkbodies, PDZK1, PDZK3, PDZK8, PDZK2, PDZK4, PDZK7 and PDZK11.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PDZK1 Antibody (L-12) sc-27279 200 µg/ml $279
PDZK1 (L-12) P sc-27279 P
(peptide)
100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PDZK1 siRNA (h) sc-106840 10 µM $258
PDZK1 siRNA (m) sc-152145 10 µM $258
PDZK1 (h)-PR sc-106840-PR 10 µM, 20 µl $23
PDZK1 (m)-PR sc-152145-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PDZK1 shRNA Plasmid (h) sc-106840-SH 20 µg $520
PDZK1 shRNA Plasmid (m) sc-152145-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PDZK1 shRNA (h) Lentiviral Particles sc-106840-V 200 µl $625
PDZK1 shRNA (m) Lentiviral Particles sc-152145-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
rat kidney extract sc-2394 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PDZK1 5174 1q21.1 NM_002614 Q5T2W1
603831
Mouse Pdzk1 59020 3 F2.1 Q9JIL4
N/A
 


Proteins containing PDZ domains play a role in a wide array of biological functions including protein scaffolding, organization of ion channels, and signal transduction. The PDZ domain containing protein PDZK1 interacts with multiple targets, including MAP17 and cMOAT and also NaPi-IIa, which implicates PDZK1 in ion channel formation. PDZK1 localizes to the plasma membrane of epithelial cells, where it is able to interact simultaneously with more than one type of channel, by utilizing its 4 PDZ domains, and thus acts as an adaptor between different cell surface receptors. Furthermore, PDZK1 is markedly upregulated in human carcinomas of epithelial origin, and the cluster formed by its association with cMOAT and MAP17 may potentially play role in multidrug resistance. Therefore, PDZK1 may be a new target for cancers cells resistance to chemotherapeutic agents.