ARP-1 Antibody (E-11): sc-271940

ARP-1 Antibody (E-11) is a mouse monoclonal IgM λ antibody that detects ARP-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ARP-1 (E-11) antibody is available as non-conjugated anti-ARP-1 antibody. ARP-1 protein, also known as COUP-TFII, plays a crucial role in regulating gene expression during development, particularly in the central nervous system. ARP-1 (E-11) monoclonal antibody binds to specific DNA response elements to modulate the activity of other transcription factors, such as retinoic acid receptors and peroxisome proliferator-activated receptors, thereby influencing various developmental processes. ARP-1 expression is tightly regulated and overlaps with COUP-TFI, highlighting ARP-1′s importance in neural differentiation and development. ARP-1 interaction with other transcription factors can lead to both activation and repression of target genes, making ARP-1 a key player in maintaining the balance of gene expression necessary for proper cellular function.

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ARP-1 Antibody (E-11) References:

1. The regulation of COUP-TFII gene expression by Ets-1 is enhanced by the steroid receptor co-activators.  |  Petit, FG., et al. 2004. Mech Ageing Dev. 125: 719-32. PMID: 15541767
2. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors.  |  Umesono, K., et al. 1991. Cell. 65: 1255-66. PMID: 1648450
3. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily.  |  Ladias, JA. and Karathanasis, SK. 1991. Science. 251: 561-5. PMID: 1899293
4. COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways.  |  Boutant, M., et al. 2012. PLoS One. 7: e30847. PMID: 22292058
5. The critical roles of COUP-TFII in tumor progression and metastasis.  |  Qin, J., et al. 2014. Cell Biosci. 4: 58. PMID: 25328664
6. COUP transcription factor is a member of the steroid receptor superfamily.  |  Wang, LH., et al. 1989. Nature. 340: 163-6. PMID: 2739739
7. Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other.  |  Miyajima, N., et al. 1988. Nucleic Acids Res. 16: 11057-74. PMID: 2905047
8. Generation of heterozygous (MCRIi030-A-1) and homozygous (MCRIi030-A-2) NR2F2/COUP-TFII knockout human iPSC lines.  |  Ferreira, LGA., et al. 2024. Stem Cell Res. 76: 103374. PMID: 38458031
9. An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development.  |  Lu, XP., et al. 1994. Mol Endocrinol. 8: 1774-88. PMID: 7708064
10. Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors.  |  Jonk, LJ., et al. 1994. Mech Dev. 47: 81-97. PMID: 7947324
11. Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors.  |  Cooney, AJ., et al. 1993. J Biol Chem. 268: 4152-60. PMID: 8382695
12. Chicken ovalbumin upstream promoter-transcription factors and their regulation.  |  Qiu, Y., et al. 1996. J Steroid Biochem Mol Biol. 56: 81-5. PMID: 8603050

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARP-1 Antibody (E-11) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-ARP-1 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARP-1 Antibody (E-11) Specifications

Alternate Product Name: ARP-1

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM lambda light chain

Amino Acids: 13-44

Epitope Target: ARP-1

Epitope Species: human

Product Reactivity/Detection: ARP-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for ARP-1 Antibody (E-11): P: Blocking Peptide, X: TransCruz Reagent

The preferred COUP-TFI antibody is COUP-TFI Antibody (H-11): sc-74561.