PNK Antibody (F-3) | Santa Cruz Biotech

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PNK Antibody (F-3): sc-271505	\| Datasheet

5 3 (Based on data analysis) 1

PNK Antibody (F-3) is a mouse monoclonal IgG_2b provided at 200 µg/ml
specific for an epitope mapping between amino acids 457-477 near the C-terminus of PNK of human origin
recommended for detection of PNK of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA

See additional PNK Antibodies.

Also see PNK Inhibitors for functional analysis of cellular responses to PNK.

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WB IP IF IHC(P)

Species	Gene Name	Gene ID	Chromosome Location	Isoform (mRNA) Accession #	Protein Accession #	OMIM™ Number

Human	PNKP	11284	19q13.42	NM_007254	NP_009185	605610
Mouse	Pnkp	59047	7 B4	NM_021549	Q9JLV6	N/A

Bifunctional polynucleotide phosphatase/kinase (PNK), also referred to as polynucleotide kinase-3'-phosphatase, is a member of the DNA 3’ phosphatase family. PNK is the protein expressed by the gene PNKP and contains a 3'-phosphatase domain with similarity to L-2-haloacid dehalogenases and a reported ATP binding site. PNK is a nuclear protein that is involved in DNA repair following damage caused by radiation or oxidation. The protein catalyzes the phosphorylation of DNA at the hydroxy termini but can also dephosphorylate its 3’-phosphate termini. The highest levels of expression of PNK occur in testis, pancreas, spleen, kidney and heart.

PNK Antibody (F-3) Data

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PNK (F-3): sc-271505. Western blot analysis of PNK expression in non-transfected: sc-117752 (A) and human PNK transfected: sc-115119 (B) 293T whole cell lysates.

PNK (F-3): sc-271505. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing nuclear staining of glandular cells.

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PNK Antibody (F-3): sc-271505