POR1 Antibody (E-3) | Santa Cruz Biotech

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POR1 Antibody (E-3): sc-271478	\| Datasheet

5 5 (Based on data analysis) 1

POR1 Antibody (E-3) is a mouse monoclonal IgG_2a provided at 200 µg/ml
raised against amino acids 1-100 mapping at the N-terminus of POR1 of human origin
recommended for detection of POR1 of human origin by WB, IP, IF, IHC(P) and ELISA

Full-length POR1 protein sequence with immunogen highlighted:

MTDGILGKAATMEIPIHGNGEARQLPEDDG See more...

MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ

See additional POR1 Antibodies.

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WB IP IF IHC(P)

Species	Gene Name	Gene ID	Chromosome Location	Isoform (mRNA) Accession #	Protein Accession #	OMIM™ Number

Human	ARFIP2	23647	11p15.4	NM_012402	NP_036534	601638
Mouse	Arfip2	76932	7 E3	NM_029802	Q8K221	N/A

POR1 (also designated arfaptin 2) was first isolated as a Rac 1 binding protein necessary for Rac-mediated Actin polymerization and the subsequent formation of membrane ruffles and lamellipodia. POR1 has also been shown to interact with the ADP ribosylation factor ARF6, a GTPase that associates with the plasma membrane and intracellular endosome vesicles, in a GTP dependent manner. The association of POR1 with ARF6 stimulates induction of Actin polymerization. POR1 appears to play a regulatory role through mul-tiple signaling pathways in the reorganization of the cytoskeletal structure.

POR1 Antibody (E-3) Data

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POR1 (E-3): sc-271478. Western blot analysis of POR1 expression in HeLa whole cell lysate.

POR1 (E-3): sc-271478. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

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POR1 Antibody (E-3): sc-271478