MafA Background Information Members of the bZIP containing Maf transcription factor family play important roles in cellular differentiation and regulation. MafA, originally identified in mammals as the pancreatic b-cell specific RIPE3b1 factor, is a transcriptional activator expressed specifically in insulin-producing cells, where it functions by binding to the critical insulin enhancer element RIPE3b. MafA is critical for generating and regulating glucose-reponsive insulin expression in b cells. The size of MafA in mammalian cell lines varies, due to posttranslational modification of the protein.
MafA (F-12)
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MafA (F-12): sc-27140. Western blot analysis of MafA expression in mouse eye (A) and mouse pancreas (B) tissue extracts.
