TES Antibody (G-9): sc-271184

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TES was originally identified as a candidate tumour suppressor gene and has been found to encode a novel focal adhesion protein called TES or Testin. TES localizes to cell-cell contacts, Actin stress fiber and interacts with a variety of cytoskeletal proteins including Zyxin, Mena, VASP, Talin and Actin. The ability of TES to associate with a-actinin, paxillin and Zyxin is dependent on the conformational state of the molecule. TES contains 3 LIM zinc-binding domains and may act as a tumor suppressor. Overexpression of the TES gene results in increased cell spreading and decreased cell motility.