Rac GAP1 Antibody (A-6): sc-271110

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A large number of low molecular weight, GTP binding proteins of the Ras superfamily have been identified. These proteins regulate many fundamental processes in all eukaryotic cells such as growth, vesicle traffic and cytoskeletal organization. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. Through this function, GAPs negatively regulate Ras-mediated signaling. Rac GAP1 (Rac GTPase activating protein 1), also known as MgcRacGAP (male germ cell Rac GTPase activating protein), ID-GAP or HsCYK-4, functions as a GAP and exhibits strong activity towards Rac 1 and Cdc42. Highly expressed in thymus, placenta and testis with lower levels in spleen and peripheral blood lymphocytes, Rac GAP1 contains one Rho-GAP domain and one phorbol-ester/DAG-type zinc finger. Rac GAP1 plays an essential role in cytokinesis, functioning as a scaffold protein as well as a GTPase regulator. During cytokinesis, Rac GAP1 is phosphorylated at multiple sites.