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MORF4L1 (W-15)-R Antibody: sc-26528-R |
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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of MORF4L1 of human origin
- recommended for detection of MORF4L1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-26528 P
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MORF4L1 Background Information The members of the mortality factor family include mortality factor 4 (MORF4), MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. The genes encoding MRG15 and MRGX map to chromosomes 15q24 and Xq22, respectively. MORF4, MORF4L1 and MRGX each contain a C-terminal leucine zipper. An association between MORF4L1, Rb (retinoblastoma tumor suppressor) and PAM14 (protein associated with MORF4L1) suggests a role for MORF4L1 in transcription regulation. MORF4L1 also associates with the histone acetyl transferase MOF. In addition, MORF4 and MRGX interact with mSin3A and TLE (transducin-like enhancer of split). The MORF/ mSin3A/TLE association may repress transcription. In Purkinje cells, MORF4L1 localizes to the dendrites and the nuclei. |
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MORF4L1 (W-15)-R
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MORF4L1 (W-15): sc-26528. Western blot analysis of MORF4L1 expression in non-transfected: sc-117752 (A) and mouse MORF4L1 transfected: sc-121745 (B) 293T whole cell lysates.
MORF4L1 (W-15): sc-26528. Western blot analysis of MORF4L1 expression in non-transfected: sc-117752 (A) and mouse MORF4L1 transfected: sc-121745 (B) 293T whole cell lysates.
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