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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of Acrp30 of human origin
- recommended for detection of precursor and mature Acrp30 and LOC387911 of human origin and precursor and mature Acrp30 of mouse and rat origin by WB, IF and ELISA; may be cross-reactive with CTRP9; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-26496 P
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
ADIPOQ |
9370 |
3q27.3 |
NM_004797 |
Q15848
|
605441 |
| Mouse |
Adipoq |
11450 |
16 B1 |
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Q60994
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N/A |
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Acrp30 Background Information
Acrp30 (adipocyte complement-related protein or AdipoQ) is a secretory protein made exclusively in adipocytes with mRNA induced over 100-fold during adipocyte differentiation. Post-transcriptional modification of Acrp30 yields several oligomeric forms of varying molecular weight, including a monomer, a dimer, a trimer, a hexamer and a polymer. Acrp30 is an abundant serum protein, secreted exclusively from fat cells, and is implicated in energy homeostasis and obesity. Due to the dysregulation of Acrp30 in cases of obesity in humans and mice and the strong structural similarity to TNFå, Acrp30 is a suspected regulator of whole body energy homeostasis. In addition, regulated exocytosis of Acrp30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated Acrp30 secretion is blocked by pharmacologic inhibitors of this enzyme. |
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Acrp30 (G-17)
Click on image to enlarge
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Acrp30 (G-17): sc-26496. Immunofluorescence staining of methanol-fixed Mia PaCa-2 cells showing cytoplasmic localization.
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