epitope mapping within an internal region of Smad5 of human origin
recommended for detection of Smad5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-26418 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-26418 X, 200 µg/0.1 ml
Smad5 Background Information Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGF∫/BMP signaling (1). Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGF∫ and activin-mediated growth modulation (2-5,8). Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members (6). Smad6 and Smad7 regulate the response to activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad family members (7,8).
Smad5 (Q-20) Product Citations
See how others have used Smad5 (Q-20): sc-26418 antibody and or Smad5 (Q-20) antibody conjugates.
