epitope mapping near the C-terminus of Smad6 of human origin
recommended for detection of Smad6 of mouse, rat and human origin by IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
Smad6 Background Information Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGF∫/BMP signaling (1). Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3
are involved in TGF∫ and activin-mediated growth
modulation (2-5,8). Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members (6). Smad6 and Smad7 regulate the response to activin/TGF∫ signaling by interfering with TGF∫-mediated phosphorylation of other Smad family
members (7,8).
