HMG-1 Background Information High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone
components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NF˚B family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone.
HMG-1 (K-12) Product Citations
See how others have used HMG-1 (K-12): sc-26351 antibody and or HMG-1 (K-12) antibody conjugates.
2 total citations
Loading citations.
HMG-1 (K-12)
Click on image to enlarge
HMG-1 (K-12): sc-26351. Western blot analysis of HMG-1 expression in non-transfected: sc-110760 (A) and human HMG-1 transfected: sc-110487 (B) 293 whole cell lysates.
HMG-1 (K-12): sc-26351. Western blot analysis of HMG-1 expression in non-transfected: sc-117752 (A) and mouse HMG-1 transfected: sc-120823 (B) 293T whole cell lysates.
HMG-1 (K-12): sc-26351. Western blot analysis of HMG-1 expression in non-transfected: sc-110760 (A) and human HMG-1 transfected: sc-110487 (B) 293 whole cell lysates.
HMG-1 (K-12): sc-26351. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nucleolar localization.
