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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of HMG-2 of human origin
- recommended for detection of HMG-2, LOC646993 and LOC441795 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-26349 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-26349 X, 200 µg/0.1 ml
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Ordering Information
Recommended Support Products:
(click button of application of choice)
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HMGB2 |
3148 |
4q34.1 |
NM_002129 |
P26583
|
163906 |
| Mouse |
Hmgb2 |
97165 |
8 B2 |
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P30681
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N/A |
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HMG-2 Background Information
High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NF˚B family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone. |
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HMG-2 (D-16)
Click on image to enlarge
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HMG-2 (D-16): sc-26349. Western blot analysis of HMG-2 expression in HeLa nuclear extract.
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