epitope mapping within an internal region of LHR of human origin
recommended for detection of LHR of human and, to a lesser extent, mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
LHR Background Information Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testis and ovaries to produce steroids (1). Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy (2). Ovaries and testis abundantly express luteinizing hormone/choriogonadotropin receptor (LHR) as a seven transmembrane, G protein-coupled receptor glycoprotein (3,4). LHR influences the protective effect of pregnancy and gonadotropin against breast cancer (5). The expression of LHR on breast carcinoma correlates in part to the degree of tumor differentiation (5). LHR-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women (5). The gene encoding human LHR maps to chromosome 2p21 (6).
LHR (K-15) Product Citations
See how others have used LHR (K-15): sc-26341 antibody and or LHR (K-15) antibody conjugates.
