epitope mapping within an internal region of TPX2 of human origin
recommended for detection of TPX2 of human and, to a lesser extent, m and r origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TPX2 Background Information TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules. Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase. Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly. TPX2 appears to play a structural role in spindle formation. TPX2 activates Eg2 in a microtubule-dependent manner by stimulating the phosphorylation and kinase activity
of Eg2. TPX2 is inactivated by binding to importin a, a nuclear import factor. Finally, the suppression of TPX2 with RNA interference causes defects in microtubule organization during mitosis.
TPX2 (F-17) Product Citations
See how others have used TPX2 (F-17): sc-26274 antibody and or TPX2 (F-17) antibody conjugates.
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TPX2 (F-17)
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TPX2 (F-17): sc-26274. Western blot analysis of human recombinant TPX2 fusion protein (A) and HeLa (B), K-562 (C), SHP-77 (D), A549 (E) and NIH/3T3 (F) whole cell lysates.
