Gfi-1 Gel Shift Oligonucleotides: sc-2623

Gfi-1 Gel Shift Oligonucleotides are short DNA sequences meticulously designed for utilization in gel shift assays, a fundamental technique in molecular biology research aimed at exploring protein-DNA interactions. The name "Gfi-1" refers to growth factor independence 1, a transcriptional repressor involved in regulating various cellular processes, including hematopoiesis, immune response, and oncogenesis. Gfi-1 is a member of the SNAG domain-containing transcription factor family and exerts its regulatory effects by binding to specific DNA sequences, known as Gfi-1 recognition elements (GREs), within the promoters of target genes. Upon binding, Gfi-1 modulates the transcriptional activity of its target genes, influencing their expression levels and cellular functions. By employing Gfi-1 Gel Shift Oligonucleotides in gel shift assays, researchers can investigate the binding kinetics, specificity, and affinity of Gfi-1 to its target DNA sequences under various experimental conditions. This technique enables the elucidation of the molecular mechanisms underlying Gfi-1-mediated gene regulation and provides insights into the complex signaling networks governing cellular processes in hematopoiesis and immune regulation.