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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of TyrRS of human origin
- recommended for detection of TyrRS of mouse, rat and human origin by IP and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-26207 P
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
YARS |
8565 |
1p35.1 |
NM_003680 |
P54577
|
608323 |
| Mouse |
Yars |
107271 |
4 D2.2 |
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Q91WQ3
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N/A |
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TyrRS Background Information
Tryptophanyl-tRNA synthetases are essential enzymes that catalyze the aminoacylation of tRNA(Trp) with tryptophan, an essential function of the cell’s protein synthesis machinery. Two forms of tryptophanyl-tRNA synthetase exist; a cytoplasmic form, named TrpRS (also known as WARS), and a mitochondrial form, named WARS2. In normal cells, human TrpRS exists as a full length form and as a truncated form designated mini TrpRS, which is produced by alternative splicing. Expression of mini TrpRS is highly stimulated in human cells by the addition of IFN-g. Although both human full length TrpRS and mini TrpRS are enzymatically active in aminoacylation, they differ in angiostatic activity. The tyrosyl-tRNA synthetase (TyrRS), a protein related to TrpRS, exists as a homodimeric enzyme that catalyzes the aminoacylation of tRNA(Tyr) by L-tyrosine. |
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TyrRS (N-16)
Click on image to enlarge
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TyrRS (N-16): sc-26207. Western blot analysis of TyrRS expression in non-transfected: sc-117752 (A) and human TyrRS transfected: sc-170741 (B) 293T whole cell lysates. TyrRS (N-16): sc-26207. Western blot analysis of TyrRS expression in HeLa whole cell lysate.
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