HTH (dG-20) Antibody: sc-26187

HTH Background Information
Homeodomain-containing Hox proteins regulate segmental identity in Drosophila in concert with two partners known as Extradenticle (EXD) and Homothorax (HTH) (1). EXD and HTH are DNA-binding, homeodomain proteins (1). Vertebrate orthologs of EXD and HTH, known as Pbx and Meis (named for a myeloid ecotropic leukemia virus integration site), respectively, are encoded by multigene families and are present in multimeric complexes together with vertebrate Homeotic (Hox) proteins (1,2). In Drosophila, differences between segments, such as the presence or absence of appendages, or the identity of structures along the anterior-posterior axis, are controlled by Hox transcription factors (2,3). Co-factor homeodomain proteins such as HTH and EXD can increase the DNA-binding specificity of Hox protein transcription factors (4). HTH binds to the homeotic cofactor Extradenticle (EXD) and translocates it to the nucleus (5). The coexpression of EXD and HTH with Distal-less is required to establish antenna fate (6).