CTCF Gel Shift Oligonucleotides: sc-2613

CTCF Gel Shift Oligonucleotides are short DNA sequences complexly synthesized for application in gel shift assays, a cornerstone technique in molecular biology research aimed at scrutinizing protein-DNA interactions. The acronym CTCF stands for CCCTC-binding factor, a highly conserved transcription factor involved in diverse cellular processes, including transcriptional regulation, chromatin organization, and genomic imprinting. CTCF binds to specific DNA sequences, known as CTCF-binding sites or insulator sequences, within the genome, where it acts as a versatile regulator of gene expression by modulating chromatin structure and facilitating long-range interactions between distant genomic regions. By utilizing CTCF Gel Shift Oligonucleotides in gel shift assays, researchers can explore the binding kinetics, specificity, and affinity of CTCF to its target DNA sequences under various experimental conditions. This technique enables the elucidation of the molecular mechanisms underlying CTCF-mediated gene regulation and provides insights into the complex architectural organization of the genome.

CTCF Gel Shift Oligonucleotides References:

1. Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription.  |  De Biase, I., et al. 2009. PLoS One. 4: e7914. PMID: 19956589
2. Identification and Functional Characterization of Cis-Regulatory Elements Controlling Expression of the Porcine ADRB2 Gene.  |  Jaeger, A., et al. 2015. Int J Biol Sci. 11: 1006-15. PMID: 26221068