 |
p-GABAB R2 (Ser 893) Antibody: sc-26129 |
| Datasheet |
|
- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-26129-R
- recommended for detection of Ser 893 phosphorylated GABAB R2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
- blocking peptide, sc-26129 P
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
GABBR2 |
9568 |
9q22.33 |
NM_005458 |
O75899
|
607340 |
| Mouse |
Gabbr2 |
242425 |
4 B1 |
|
Q80T41
|
N/A |
| |
GABAB R2 Background Information
GAD-65 and GAD-67, glutamate decarboxylases, catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA (gamma-aminobutyric acid) acts as the main inhibitory transmitter by increasing a Cl-- conductance that inhibits neuronal firing. GABA activates both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Members of the GABAA receptor family include GABAA Rå1-6, GABAA R ∫1-3, GABAA R©1-3, GABAA R∂, GABAA Ré, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1å and GABAB R1∫. PKA phosphorylates GABABR2 at Ser 893. This phosphorylation appears to enhance the membrane stability of GABAB R2 . |
|
|
p-GABAB R2 (Ser 893)
Click on image to enlarge
|
|
p-GABAB R2 (Ser 893)-R: sc-26129-R. Western blot analysis of GABAB R2 phosphorylation in 293T whole cell lysate.
p-GABAB R2 (Ser 893)-R: sc-26129-R. Western blot analysis of GABAB R2 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.
p-GABAB R2 (Ser 893)-R: sc-26129-R. Western blot analysis of GABAB R2 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) rat brain tissue extracts.
|
|
Download
|
|
