epitope mapping near the C-terminus of coilin of human origin
recommended for detection of coilin of mouse, rat and human origin by ELISA; also reactive with additional species, including equine, canine, bovine and porcine
coilin Background Information Coilin is the primary protein of nuclear coiled (Cajal) bodies. Cajal bodies are small nuclear organelles and contain many proteins involved in RNA transcription and processing. Coilin is a self-associating protein with a nucleolar localization signal. It is essential for the proper formation of Cajal bodies and for the recruitment of snRNP and survival motor neuron (SMN) complex proteins to Cajal bodies. Coilin directly binds SMN proteins in the recruitment process and competes with SmB’ for SMN interactions. In the developing organism, Cajal bodies play a role in the assembly of the nucleolus. While the N-terminus of coilin contains the self-associating domain, the C-terminus of coilin regulates the number of Cajal bodies present in the cell.
