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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of PQBP-1 of human origin
- recommended for detection of PQBP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-26054 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-26054 X, 200 µg/0.1 ml
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Ordering Information
Recommended Support Products:
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PQBP-1 Background Information
Polyglutamine(Q) tract binding protein-1 (PQBP-1) is a transcription repressor that associates with polyglutamine tract-containing transcription regulators and causative genes for neurodegenerative disorders (1-4). Hepta- and di-amino acid repeat sequences rich in polar residues are essential for PQBP-1 to interact with polyglutamine tract-containing proteins (i.e. huntingtin, androgen receptor and Brain-2) (1,2,5). PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence Ca2+-dependent phospholipid signaling (6,7). PQBP-1 localizes to the nucleus and is present in neurons throughout the brain, with abundant levels in hippocampus, cerebellar cortex and olfactory bulb (1,3). The human PQBP-1 gene maps to chromosome Xp11.23 (5,8). |
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PQBP-1 (C-20)
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PQBP-1 (C-20): sc-26054. Western blot analysis of PQBP-1 expression in Sol8 nuclear extract.
PQBP-1 (C-20): sc-26054. Western blot analysis of PQBP-1 expression in non-transfected: sc-117752 (A) and mouse PQBP-1 transfected: sc-122739 (B) 293T whole cell lysates. |
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