epitope mapping near the N-terminus of PQBP-1 of human origin
recommended for detection of PQBP-1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-26052 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-26052 X, 200 µg/0.1 ml
PQBP-1 Background Information Polyglutamine(Q) tract binding protein-1 (PQBP-1) is a transcription repressor that associates with polyglutamine tract-containing transcription regulators and causative genes for neurodegenerative disorders (1-4). Hepta- and di-amino acid repeat sequences rich in polar residues are essential for PQBP-1 to interact with polyglutamine tract-containing proteins (i.e. huntingtin, androgen receptor and Brain-2) (1,2,5). PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence Ca2+-dependent phospholipid signaling (6,7). PQBP-1 localizes to the nucleus and is present in neurons throughout the brain, with abundant levels in hippocampus, cerebellar cortex and olfactory bulb (1,3). The human PQBP-1 gene maps to chromosome Xp11.23 (5,8).
PQBP-1 (N-20) Product Citations
See how others have used PQBP-1 (N-20): sc-26052 antibody and or PQBP-1 (N-20) antibody conjugates.
