epitope mapping at the N-terminus of ARA160 of human origin
recommended for detection of ARA160 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
blocking peptide, sc-25961 P
TransCruz reagent for Gel Supershift and ChIP applications, sc-25961 X, 200 µg/0.1 ml
ARA160 Background Information Androgens exhibit a wide range of effects on the development, maintenance and regulation of male phenotype and reproductive physiology in males. The androgen receptor (AR) is a member of the steroid superfamily of ligand-dependent transcription factors. ARs bind the two biologically active androgens, testosterone (T) and dihydrotestosterone (DHT). ARA54 contains a RING finger and functions as an AR coactivator. Testis, thymus, spleen, colon, pro-state and uterus express ARA54 at high levels. ARA160 associates with an ATP-dependent chromatin remodeling factor known as the SNF/SWI complex. The FXXLF motif present in AR coactivators mediates their interaction with AR but not their transcription-related activity. The genes encoding human ARA54 and ARA160 map to chromosomes 5q23.3-q31.1 and 3p21-p12, respectively.
