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home » Signaling Intermediates » COMT Antibody / COMT Antibodies » COMT (FL-271): sc-25844

COMT (FL-271) Antibody: sc-25844

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 1-271 representing full length Catechol-O-Methyltransferase of human origin
  • recommended for detection of soluble and membrane bound COMT of mouse, rat and human origin by WB, IP, IF and ELISA
 
Additional COMT Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human COMT 1312 22q11.21 NM_000754, NM_007310 P21964
 181500
Mouse Comt 12846 16 A3 O88587
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
COMT (FL-271) sc-25844 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
COMT siRNA (h) sc-43693 10 µM $258
COMT siRNA (m) sc-77372 10 µM $258
COMT siRNA (r) sc-156149 10 µM $258
COMT (h)-PR sc-43693-PR 10 µM $23
COMT (m)-PR sc-77372-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
COMT shRNA Plasmid (h) sc-43693-SH 20 µg $520
COMT shRNA Plasmid (m) sc-77372-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
COMT shRNA (h) Lentiviral Particles sc-43693-V 200 µl $625
COMT shRNA (m) Lentiviral Particles sc-77372-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IMR-32 Cell Lysate sc-2409 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
JAR Cell Lysate sc-2276 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
COMT (h2): 293T Lysate sc-128345 100µg/200µl $205
COMT (h3): 293T Lysate sc-128346 100µg/200µl $205
COMT (h): 293T Lysate sc-111755 100µg/200µl $205

COMT Background Information
Catechol-O-methyltransferase (COMT) plays a crucial role in the regulation of central dopaminergic systems by catalyzing the inactivation of catechol-amines. It is widely distributed in most tissues in soluble and membrane-bound forms. COMT-mediated methylation metabolism of catecholamine neurotransmitters is a first-line detoxification pathway. A Val158Met polymorphism of the COMT gene affects activity of the enzyme and influences performance and efficiency of the prefrontal cortex of the brain. Sequential conversion of estradiol to methoxyestradiol by COMT, contributes to the antimitogenic effects of estradiol on vascular smooth muscle cell growth via estrogen receptor-independent mechanisms.

COMT (FL-271) Product Citations
See how others have used COMT (FL-271): sc-25844 antibody and or COMT (FL-271) antibody conjugates.


1 total citations
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COMT (FL-271)
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sc-25844
COMT (FL-271): sc-25844. Western blot analysis of COMT expression in IMR-32 whole cell lysate.
sc-25844
COMT (FL-271): sc-25844. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and membrane localization.
sc-25844
COMT (FL-271): sc-25844. Western blot analysis of COMT expression in non-transfected 293T: sc-117752 (A), human COMT transfected 293T: sc-111755 (B) and K-562 (C) whole cell lysates.
sc-25844
COMT (FL-271): sc-25844. Western blot analysis of COMT expression in non-transfected 293T: sc-117752 (A), human COMT transfected 293T: sc-111755 (B) and Jurkat (C) whole cell lysates.
sc-25844
COMT (FL-271): sc-25844. Western blot analysis of COMT expression in non-transfected 293T: sc-117752 (A), human COMT transfected 293T: sc-128345 (B) and JAR (C) whole cell lysates.
sc-25844
COMT (FL-271): sc-25844. Western blot analysis of COMT expression in non-transfected 293T: sc-117752 (A), human COMT transfected 293T: sc-128346 (B) and K-562 (C) whole cell lysates.
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