G6Pase-α (H-60) Antibody: sc-25840

G6Pase-α Background Information
Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate (G6P) in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-å, a second form, designated G6Pase-∫, contributes to blood glucose homeostasis in a wider range of tissues. Glucocorticoids stimulate the expression of the G6Pase gene while Insulin rapidly inhibits expression via the thymine-rich Insulin response element located within the promoter of the G6Pase gene. Due to its necessary involvement in normal glucose metabolism, G6Pase plays an integral role in Diabetes and glycogen storage diseases (GSDs). The presence of different isoforms may explain the ability of some individuals with GSDs to still produce glucose, despite their lack of functional G6Pase-å.