epitope corresponding to amino acids 101-180 mapping within an internal region of heparanase 1 of human origin
recommended for detection of heparanase 1 of human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine and bovine
HPA1 Background Information Heparanases (HPA) degrade heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix and play animportant role in the extravasation of blood-borne tumor cells and inflammatory leukocytes. HPA1 dismantles the subendothelial basal membrane and facilitates the metastasis of blood-borne tumor cells. Furthermore, HPA1 induces angiogenesis and likely promotes the vascularization of tumors. Upon degradation, HPAs free growth factors and cytokines that stimulate cell proliferation and chemotaxis. Fibroblasts endocytose extracellular HPA1 for cytoplasmic accumulation in vitro. Proteolytic processing at the cell surface of a precursor begets an active form of HPA1. The gene encoding human HPA1 maps to chromosome 4q21.3 .
HPA1 (H-80) Product Citations
See how others have used HPA1 (H-80): sc-25825 antibody and or HPA1 (H-80) antibody conjugates.
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HPA1 (H-80)
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HPA1 (H-80): sc-25825. Western blot analysis of active HPA1 expression in HeLa whole cell lysate.
HPA1 (H-80): sc-25825. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
HPA1 (H-80): sc-25825. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and membrane localization.
