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UCH-L1 Antibody (H-40): sc-25800

 |  Datasheet

(Based on data analysis)

  • UCH-L1 Antibody (H-40) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 184-223 mapping at the C-terminus of UCH-L1 of human origin
  • recommended for detection of UCH-L1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • See 2 citations for UCH-L1 Antibody (H-40)
 
Full-length UCH-L1 protein sequence with immunogen highlighted:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA

See additional UCH-L Antibodies including UCH-L5, UCH-L4, UCH-L3, UCH-L1 and UCH-L.

Also see UCH-L1 Inhibitors for functional analysis of cellular responses to UCH-L1.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
UCH-L1 Antibody (H-40) sc-25800 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
UCH-L1 siRNA (h) sc-42304 10 µM $258
UCH-L1 siRNA (m) sc-42305 10 µM $258
UCH-L1 (h)-PR sc-42304-PR 10 µM, 20 µl $23
UCH-L1 (m)-PR sc-42305-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
UCH-L1 shRNA Plasmid (h) sc-42304-SH 20 µg $520
UCH-L1 shRNA Plasmid (m) sc-42305-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
UCH-L1 shRNA (h) Lentiviral Particles sc-42304-V 200 µl $625
UCH-L1 shRNA (m) Lentiviral Particles sc-42305-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
UCH-L1 (h): 293T Lysate sc-176636 100 µg/200 µl $205
IMR-32 Cell Lysate sc-2409 500 µg/200 µl $104
mouse brain extract sc-2253 500 µg/200 µl $104
rat brain extract sc-2392 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human UCHL1 7345 4p13 NM_004181 P09936
 191342
Mouse Uchl1 22223 5 C3.1 Q9R0P9
 N/A
 

UCH-L1 (ubiquitin C-terminal hydrolase) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCH-L1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. UCH-L1 is expressed in brain neurons. Examination of specific brain regions reveals expression in all areas tested, particularly in the substantia nigra. UCH-L1 represents 1-2% of total soluble brain protein. Its occurrence in Lewy bodies and its function in the proteasome pathway make it a compelling candidate gene in Parkinson disease. The gene which encodes UCH-L1 maps to human chromosome 4p13. The 230 amino acid human UCH-L3 protein is 54% identical to that of UCH-L1. UCH-L3 is the predominant thiol protease and has high-affinity binding sites for ubiquitin.

UCH-L1 Antibody (H-40) Product Citations
See how others have used UCH-L1 Antibody (H-40) and or UCH-L1 Antibody (H-40) conjugates.


2 total citations
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UCH-L1 Antibody (H-40) Data
Click on image to enlarge
sc-25800
UCH-L1 (H-40): sc-25800. Immunofluorescence staining of normal mouse intestine frozen section showing cytoplasmic staining.
sc-25800
UCH-L1 (H-40): sc-25800. Western blot analysis of UCH-L1 expression in rat brain tissue extract.
sc-25800
UCH-L1 (H-40): sc-25800. Western blot analysis of UCH-L1 expression in non-transfected: sc-117752 (A) and human UCH-L1 transfected: sc-176636 (B) 293T whole cell lysates.
sc-25800
UCH-L1 (H-40): sc-25800. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of Islets of Langerhans and glandular cells.
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