Molecular structure of Ethyl bromodifluoroacetate, CAS Number: 667-27-6
Ethyl bromodifluoroacetate (CAS 667-27-6)
CAS Number:
667-27-6
Molecular Weight:
202.98
Molecular Formula:
C4H5BrF2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ethyl bromodifluoroacetate employed in the synthesis of pharmaceuticals, agrochemicals, and diverse organic compounds, it serves as a key building block in these intricate processes. Furthermore, its significance extends to acting as a catalyst in polymer production and as a reactant in the manufacturing of fluorinated polymers. With its reactivity and potential, ethyl bromodifluoroacetate finds application as a reagent in synthesizing fluorinated compounds and as a catalyst in the production of fluorinated polymers, which are integral to the fabrication of medical devices. Ethyl bromide acts as a nucleophile, while difluoroacetic acid assumes the role of an electrophile. This reaction, conducted in an aprotic solvent such as dichloromethane, is further refined through the isolation of the product via distillation.
Ethyl bromodifluoroacetate (CAS 667-27-6) References
- Copper-mediated, palladium-catalyzed cross-coupling of 3-iodochromones, thiochromones, and quinolones with ethyl bromodifluoroacetate. | Han, X., et al. 2013. J Org Chem. 78: 4850-6. PMID: 23594098
- Stereoselectivity of the Honda-Reformatsky reaction in reactions with ethyl bromodifluoroacetate with α-oxygenated sulfinylimines. | Fontenelle, CQ., et al. 2014. J Org Chem. 79: 4186-95. PMID: 24746314
- Visible-light-mediated radical aryldifluoroacetylation of alkynes with ethyl bromodifluoroacetate for the synthesis of 3-difluoroacetylated coumarins. | Fu, W., et al. 2015. J Org Chem. 80: 4766-70. PMID: 25843358
- Palladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides. | Xia, T., et al. 2017. Org Lett. 19: 2610-2613. PMID: 28467714
- Copper-Catalyzed Bromodifluoroacetylation of Alkenes with Ethyl Bromodifluoroacetate. | Li, D., et al. 2018. J Org Chem. 83: 10445-10452. PMID: 29929363
- Dual role of ethyl bromodifluoroacetate in the formation of fluorine-containing heteroaromatic compounds. | Ma, X., et al. 2018. Chem Commun (Camb). 54: 8960-8963. PMID: 29932181
- Copper-Catalyzed N-Formylation of Amines through Tandem Amination/Hydrolysis/Decarboxylation Reaction of Ethyl Bromodifluoroacetate. | Li, XF., et al. 2018. J Org Chem. 83: 12815-12821. PMID: 30230326
- Transition metal-free assembly of 1,3,5-triazines using ethyl bromodifluoroacetate as C1 source. | Yu, X., et al. 2019. Chem Commun (Camb). 55: 8079-8082. PMID: 31231730
- Palladium-Catalyzed Carboxylate-Assisted Ethoxycarboxylation of Aromatic Acids To Synthesize Monoethyl Phthalate Derivatives with Ethyl Bromodifluoroacetate. | Tao, N., et al. 2019. Org Lett. 21: 8607-8610. PMID: 31621337
- Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate. | Hou, X., et al. 2020. Org Lett. 22: 9313-9318. PMID: 33197193
- N-Difluoromethylation of N-pyridyl-substituted anilines with ethyl bromodifluoroacetate. | Duan, J., et al. 2022. Org Biomol Chem. 20: 1883-1887. PMID: 35171189
- Palladium-catalyzed difluoroalkylative carbonylation of styrenes toward difluoropentanedioates. | Bao, ZP., et al. 2022. Chem Sci. 13: 9387-9391. PMID: 36093028
- Copper-Catalyzed Difluoroalkylation Reaction. | Dong, DQ., et al. 2022. Molecules. 27: PMID: 36500553
- Copper-catalyzed selective C5-H bromination and difluoromethylation of 8-aminoquinoline amides using ethyl bromodifluoroacetate as the bifunctional reagent. | Shao, C., et al. 2023. RSC Adv. 13: 6993-6999. PMID: 36874938
- Copper-Catalyzed Radical Addition of Alkynols to Synthesize Difluoroheterocyclic Compounds. | Ke, F., et al. 2023. Org Lett. 25: 2733-2738. PMID: 37022986
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ethyl bromodifluoroacetate, 5 g | sc-257498 | 5 g | $69.00 | |||
Ethyl bromodifluoroacetate, 500 g | sc-257498A | 500 g | $306.00 |