Stat1 Gel Shift Oligonucleotides: sc-2573

Stat1 Gel Shift Oligonucleotides are short DNA sequences meticulously crafted for use in gel shift assays, a fundamental technique in molecular biology research for investigating protein-DNA interactions. These oligonucleotides derive their name from Signal Transducer and Activator of Transcription 1 (Stat1), a crucial transcription factor in cytokine signaling pathways and cellular processes such as immune response, cell proliferation, and antiviral defense. Upon activation by cytokines such as interferons, Stat1 translocates to the nucleus and binds to specific DNA sequences, known as Stat1 binding sites, within the promoters of target genes, thereby modulating their transcriptional activity. By employing Stat1 Gel Shift Oligonucleotides in gel shift assays, researchers can explore the binding kinetics, specificity, and affinity of Stat1 to its target DNA sequences under various experimental conditions. This technique enables the elucidation of the molecular mechanisms underlying Stat1-mediated gene regulation and provides insights into the complex signaling networks governing cellular responses to cytokine signaling.

Stat1 Gel Shift Oligonucleotides References:

1. Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.  |  Bowie, AG. and O′Neill, LA. 2000. J Immunol. 165: 7180-8. PMID: 11120850
2. STAT1 binds to the herpes simplex virus type 1 latency-associated transcript promoter.  |  Kriesel, JD., et al. 2004. J Neurovirol. 10: 12-20. PMID: 14982724
3. Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs.  |  Sanguino, E., et al. 2004. Biochem Pharmacol. 68: 1411-21. PMID: 15345331
4. Role of Janus kinase/signal transducer and activator of transcription pathway in regulation of expression and inflammation-promoting activity of high mobility group box protein 1 in rat peritoneal macrophages.  |  Liu, H., et al. 2007. Shock. 27: 55-60. PMID: 17172981
5. 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells.  |  Panzer, U., et al. 2008. Nephrol Dial Transplant. 23: 3776-85. PMID: 18596134
6. Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response.  |  Li, HS., et al. 2011. Blood. 118: 3879-89. PMID: 21828128
7. Regulatory effects of the JAK3/STAT1 pathway on the release of secreted phospholipase A2-IIA in microvascular endothelial cells of the injured brain.  |  Wang, G., et al. 2012. J Neuroinflammation. 9: 170. PMID: 22788969