epitope corresponding to amino acids 541-610 mapping near the C-terminus of NUMB of human origin
recommended for detection of NUMB of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and porcine
agarose conjugate for IP studies, sc-25668 AC, 500 µg/0.25 ml agarose
NUMB Background Information Neuronal cell fate decisions are directed in Drosophila by NUMB, a signaling adapter protein with two protein-protein interaction domains: a phosphotyrosine-binding domain and a proline-rich SH3-binding region (PRR). Mammalian NUMB homologs play a role in the determination of cell fates during development and bind with EPS15, LNX1, and NOTCH1. Conditional mouse mutants with deletion of NUMB in developing sensory ganglia show a reduction in axonal arborization in afferent fibers. Changes in cellular calcium homeostasis influences NUMB-dependent cell fate decisions during development of the nervous system. Chicken NUMB (c-NUMB) protein is localized to the basal cortex of mitotic neuroepithelial cells.
NUMB (H-70) Product Citations
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NUMB (H-70)
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NUMB (H-70): sc-25668. Western blot analysis of NUMB expression in T98G whole cell lysate.
NUMB (H-70): sc-25668. Western blot analysis of NUMB expression in A549 whole cell lysate.
