epitope corresponding to amino acids 42-110 mapping near the N-terminus of Ral GDS of human origin
recommended for detection of Ral GDS of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and avian
Ral GDS Background Information Ral A and Ral B constitute a distinct subfamily of Ras-related GTPases (i.e., GDP/GTP binding proteins) (1-3). Ral proteins are activated by a unique nucleotide exchange factor, Ral GDS, and deactivated by a distinct GTPase-activating protein (4,5). Unlike Ras proteins, Ral A and Ral B fail to induce transformed foci when activated variants are expressed in various recipient cells (1). A potential downstream target of Ral, designated Ral BP-1, has been shown to contain a Rho-GTPase-activating domain (1). This Rho-GTPase-activating domain interacts preferentially with the Rho family member Cdc42 (1). A Ras/Ral signaling pathway has been reported to mediate phospholipase D (PLD) activation by v-Src, thus indicating PLD as another downstream target of Ral A (6).
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Ral GDS (H-110)
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Ral GDS (H-110): sc-25636. Western blot analysis of Ral GDS expression in non-transfected 293T: sc-117752 (A), mouse Ral GDS transfected 293T: sc-127440 (B) and HeLa (C) whole cell lysates.
Ral GDS (H-110): sc-25636. Western blot analysis of Ral GDS expression in MIA PaCa-2 whole cell lysate.
