RAR (DR-5) Gel Shift Oligonucleotides: sc-2559

RAR (DR-5) Gel Shift Oligonucleotides are short DNA sequences specifically designed for use in gel shift assays, a pivotal technique in molecular biology research aimed at examining protein-DNA interactions. The term "RAR" refers to the retinoic acid receptor (RAR), a member of the nuclear receptor superfamily crucial for mediating the biological effects of retinoic acid, a derivative of vitamin A. RAR binds to specific DNA sequences known as retinoic acid response elements (RAREs), including the DR-5 motif, within the promoters of target genes, thereby modulating their transcriptional activity in response to retinoic acid signaling. By employing RAR (DR-5) Gel Shift Oligonucleotides in gel shift assays, researchers investigate the binding kinetics, specificity, and affinity of RAR to DR-5 motifs under diverse experimental conditions. This technique enables the elucidation of the molecular mechanisms underlying RAR-mediated gene regulation and provides insights into the complex signaling networks governing cellular responses to retinoic acid signaling.

RAR (DR-5) Gel Shift Oligonucleotides References:

1. A novel RARα/CAR-mediated mechanism for regulation of human organic solute transporter-β gene expression.  |  Xu, S., et al. 2014. Am J Physiol Gastrointest Liver Physiol. 306: G154-62. PMID: 24264050
2. All-trans-retinoic acid inhibition of Pro alpha1(I) collagen gene expression in fetal rat skin fibroblasts: identification of a retinoic acid response element in the Pro alpha1(I) collagen gene.  |  Meisler, NT., et al. 1997. J Invest Dermatol. 108: 476-81. PMID: 9077477