epitope corresponding to amino acids 826-889 of IRP-1 of human origin
recommended for detection of IRP-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine, porcine and avian
IRP-1 Background Information Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
IRP-1 (H-64) Product Citations
See how others have used IRP-1 (H-64): sc-25535 antibody and or IRP-1 (H-64) antibody conjugates.
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IRP-1 (H-64)
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IRP-1 (H-64): sc-25535. Western blot analysis of IRP-1 expression in non-transfected: sc-117752 (A) and mouse IRP-1 transfected: sc-125502 (B) 293T whole cell lysates.
