AR Gel Shift Oligonucleotides: sc-2551

AR Gel Shift Oligonucleotides are short DNA sequences engineered for use in gel shift assays, a foundational method in molecular biology research aimed at exploring protein-DNA interactions. The designation "AR" corresponds to the androgen receptor (AR), a pivotal transcription factor belonging to the nuclear receptor superfamily. AR is renowned for its central role in mediating the effects of androgen hormones, regulating gene expression pivotal in male sexual development, reproductive function, and other physiological processes. Upon activation by androgens, such as testosterone and dihydrotestosterone, AR translocates to the nucleus and binds to specific DNA sequences, known as androgen response elements (AREs), within the promoters of target genes. By employing AR Gel Shift Oligonucleotides in gel shift assays, researchers scrutinize the binding kinetics, specificity, and affinity of AR to AREs under varied experimental conditions. This method enables the elucidation of the molecular mechanisms underpinning AR-mediated gene regulation and offers insights into the signaling networks governing cellular responses to androgen signaling.